I-Pharmacodynamic damamycin ingeyama-antibiotic e-aminoglycoside, futhi inomphumela olinganiselayo wokuvimbela ezinhlobonhlobo zama-bacterium angenayo igram-negative, njenge-escherichia coli, i-salmonella, i-shigella, i-proteus njalonjalo. Izwela ku-streptococcus, pneumococcus, staphylococcus epidermidis kanye ne-mycoplasma ethile (njenge-mycoplasma gallinarum, mycoplasma turkey, mycoplasma synovialis, njll.). Ayizweli kakhulu ku-streptococcus viridis kanye ne-staphylococcus aureus. Ngokuvamile imelana ne-pseudomonas aeruginosa kanye ne-treponemas. Amagciwane asemathunjini amelana kakhulu ne-megamycin, kodwa awabonisi ukumelana ne-streptomycin. I-Lincomycin inomsebenzi omuhle wokulwa namagciwane ngokumelene namagciwane anaerobic, njenge-clostridium, i-peptococcus, i-peptostreptococcus, i-clostridium tetanus, i-clostridium perfringens kanye ne-actinomyces eminingi. I-Lincomycin isebenza ngokuyinhloko engxenyeni yama-50s ye-ribosomes yebhaktheriya, ethinta ukwakheka kwamaprotheni ngokuvimbela ukunwetshwa kweketango le-peptide.
I-Pharmacokinetics kuphela i-7% ye-lincomycin imuncwa ngemva kokuphathwa kwangaphakathi, kodwa igcina ukugxila okuphezulu emgudwini wamathumbu. Ukuhlushwa kwezicubu zomuthi kuphansi kune-serum concentration. Akulula ukufaka uketshezi lwe-cerebrospinal noma iso, futhi izinga lokubopha lamaprotheni e-plasma aliphezulu. Izidakamizwa eziningi zikhishwa ngokuhlunga kwe-glomerular ngendlela yazo yasekuqaleni. I-bioavailability ye-lincomycin ingu-30% ~ 40% ngokumuncwa okungalungile ekuphathweni ngomlomo. Izinga lokumuncwa kanye nenani le-lincomycin lingancishiswa ngokuphakelwa okuxubile. Izinkukhu zanikezwa u-50mg walo mkhiqizo (oncibilikiswe emanzini okuphuza) ngekhilogremu ngayinye yesisindo somzimba izinsuku ezingu-7. Ngesikhathi sokuhlolwa, i-plasma lincomycin yafinyelela ku-0.14 μ g/ml, kuyilapho ukugcwala kwe-daguanmycin bekukuncane kakhulu. Ngemuva kwezinsuku eziyi-7 zokuhlolwa, idlule i-0.1μg/ml.
1. Ihlanganiswe ne-lincomycin, ingakhuphula kakhulu umsebenzi we-antibacterial ngokumelene ne-mycoplasma futhi yandise i-spectrum ye-antibacterial.
2. Inhlanganisela ye-lincomycin kanye nemithi ye-anticholinesterase inganciphisa ukusebenza kokugcina.
3. Ihlanganiswe ne-erythromycin inomphumela ophikisayo.
Ama-antibiotics. Kumagciwane e-Gram-negative, amagciwane e-Gram-positive kanye nokutheleleka kwe-mycoplasma.
Isiphuzo esixutshwe: 100g walo mkhiqizo oxutshwe namanzi 200 ~ 300kg wengulube kanye no-50 ~ 100kg wenkukhu izinsuku ezingu-3 ~ 5. Ukudla okuxubile: 100g ukudla okuxubile 100kg kwezingulube kanye 50kg izinkukhu, esetshenziswa izinsuku 5 kuya 7.
Hlwanyela ukunakekelwa kwezempilo: Kusukela ezinsukwini eziyi-7 ngaphambi kokubeletha kuya ezinsukwini eziyi-7 ngemuva kokubeletha, i-100g yalo mkhiqizo ixubene ne-100kg, noma i-200kg namanzi. Ukunakekelwa kwezempilo kwezingulube: Ngaphambi nangemuva kokulunyulwa kanye nesigaba senkulisa, 100g hlanganisa u-100kg, noma amanzi angama-200kg.
Akukho ukusabela okubi okuye kwabonwa lapho kusetshenziswa ngokuya ngokusetshenziswa okunqunyiwe kanye nomthamo.