I-Pharmacodynamic lincomycin ingeyama-antibiotic e-lincoamine, iyi-ejenti ye-bacteriostatic, amagciwane azwelayo afaka i-staphylococcus aureus (kuhlanganise nezinhlobo ezimelana ne-penicillin), i-streptococcus, i-pneumococcus, i-bacillus anthracis, i-erysipelas suis, i-mycoplasma ethile (i-mycoplasma plasmaissuissal synovialis), i-leptospirosis kanye ne-anaerobic bacteria (njenge-clostridium difficile, i-clostridium tetanus, i-clostridium percapsulatus kanye ne-actinomyces eminingi). Isebenza kakhulu ku-50s subunit ye-ribosome yebhaktheriya, futhi isebenzisa umphumela wokulwa namagciwane ngokuvimbela ukunwetshwa kweketango le-peptide futhi ithinte ukwakheka kwamaprotheni.
Ukumuncwa kwakushesha ngemva komjovo we-intramuscular, ngomjovo owodwa we-intramuscular we-11mg / kg ezingulubeni kanye nokuhlushwa kwegazi eliphezulu kwe-6.25μg / ml. Izinga lokubopha amaprotheni e-plasma lalingu-57% - 72%. Isakazwa kabanzi ku-vivo, ngevolumu ebonakalayo yokusabalalisa kuka-2.8 l/kg ezingulubeni. Kusatshalaliswa kabanzi oketshezini oluhlukahlukene lomzimba kanye nezicubu (kuhlanganise nethambo), lapho ukugcwala kwesibindi nezinso kuphakeme kakhulu, futhi ukugcwala komuthi wezicubu kuphakeme izikhathi eziningana kuneserum ngesikhathi esifanayo. Ingangena ku-placenta, kodwa akulula ukungena emgodleni wegazi-ubuchopho, futhi kunzima ukufinyelela ukuhlushwa okuphumelelayo komuthi ku-cerebrospinal fluid lapho ukuvuvukala kwenzeka. Ingasatshalaliswa obisini, futhi ukugxila obisini kuyafana nalokho ku-plasma. Ingxenye yomuthi igaywa esibindini, futhi ifomu lesidakamizwa kanye nama-metabolites alo akhishwa nge-bile, umchamo nobisi. Ukukhishwa esitulweni kungabambezeleka izinsuku ezimbalwa, ngakho-ke kunomphumela ovimbelayo kuma-microorganisms azwelayo emathunjini.
1. Uma ihlanganiswa ne-gentamicin, inomphumela we-synergistic kubhaktheriya e-gram-positive njenge-staphylococcus ne-streptococcus.
2. Uma kuhlanganiswe nama-aminoglycosides kanye nama-antibiotic e-polypeptide, kungase kuthuthukise umphumela wokuvimba ekuhlanganeni kwe-neuromuscular. Ihlanganiswe ne-erythromycin inomphumela ophikisayo, ngoba indawo yesenzo iyafana, futhi i-erythromycin inobudlelwane obuqinile neyunithi yama-50s yama-ribosomes ebhaktheriya kunalo mkhiqizo.
3. Akufanele kuhlanganiswe nezidakamizwa ze-antidiarrheal ezivimbela i-peristalsis yamathumbu futhi aqukethe ubumba olumhlophe. 4. Kukhona ukungahambisani ne-kanamycin, neomycin, njll.
Ama-antibiotic e-Lincoamine. Ukutheleleka kwebhaktheriya e-gram-positive, kungabuye kusetshenziselwe i-treponemosis ne-mycoplasma nezinye izifo.
Umjovo we-Intramuscular: Umthamo owodwa, 0.0165 ~ 0.033ml nge-1kg isisindo somzimba wamahhashi nezinkomo, 0.033ml wezimvu nezingulube, kanye ngosuku; 0.033ml wezinja namakati, kabili ngosuku, izinsuku ezi-3 kuya kweziyi-5.
Umjovo we-intramuscular ungabangela uhudo lwesikhashana noma indle ethambile. Nakuba kungavamile, izinyathelo ezidingekayo kufanele zithathwe ukuze kuvinjelwe ukuphelelwa amanzi emzimbeni uma kwenzeka.
