10% Umjovo we-Iron Dextran

I-Pharmacodynamic iron iyisakhi esiyinhloko se-hemoglobin ne-myoglobin. I-Hemoglobin iyinhloko ethwala umoya-mpilo emangqamuzaneni abomvu egazi. I-Myoglobin yilapho amangqamuzana emisipha egcina umoya-mpilo ukusiza ukuwuhlinzeka emisipha ngesikhathi sokuzivocavoca. Iningi lama-enzyme nezici ezihilelekile kumjikelezo we-tricarboxylic acid aqukethe i-iron noma asebenza kuphela lapho kukhona insimbi. Ngakho-ke, ngaphezu kokuhlanganiswa kwe-hemoglobin esheshayo, izimpawu ezihlobene nokuntuleka kwe-iron kwezicubu kanye nokuncipha komsebenzi wama-enzyme ane-iron, njengokukhubazeka kokukhula, ukungahambi kahle kokuziphatha, nokukhubazeka ngokomzimba, zingalungiseka kancane kancane ngemva kokwengezwa kwensimbi esebenzayo ezilwaneni ezingenayo insimbi. I-Pharmacokinetic iron yomjovo imuncwa ngokushesha kunensimbi yomlomo; ngemva kokujova emisipha ye-iron dextran, ukugcwala kwegazi kwafinyelela umvuthwandaba emahoreni angama-24-48, futhi i-molecule yayo yayinkulu. Yathathwa yimikhumbi ye-lymphatic bese idluliselwa egazini, futhi ukuhlushwa kwegazi kwanda kancane; ngemva kokumuncwa ngomjovo nge-intravenous noma intramuscular in the blood circulation, iba yi-phagocytic futhi iboliswe ibe yi-iron ne-dextran nge-mononuclear phagocytic cell system. Ngemva kokumuncwa, ama-ion ensimbi afakwa oxidized kuma-ion ferric nge-ceruloplasmin egazini, bese ebopha kuma-receptors e-transferrin, afake amaseli ngendlela ye-pinocytosis yamangqamuzana e-hematopoietic, noma aqongelele ngendlela ye-ferritin noma i-hemosiderin esibindini, ubende, umnkantsha nezinye izinhlelo ze-mononuclear cellar. Izinga lokubopha amaprotheni liphezulu ku-hemoglobin, kodwa liphansi ku-myoglobin, ama-enzyme namaprotheni ahambisa insimbi, kanye ne-ferritin ephansi noma i-hemosiderin.