I-Pharmacodynamics flufenicol iyi-antibiotic ye-spectrum ebanzi.
Yama-aminools, i-bacteriosuppressor, futhi isebenza ngokubopha ne-ribosome 50s subunit ukuvimbela ukuhlanganiswa kwamaprotheni ebhaktheriya. Inomsebenzi oqinile we-antibacterial ngokumelene nezinhlobonhlobo zamagciwane e-gram-positive kanye ne-gram-negative. I-Pasteurella hemolyticus, i-pasteurella multocida kanye ne-actinobacillus suis pleuropneumoniae zazizwela kakhulu ku-flufenicol. I-In vitro, umsebenzi we-antimicrobial we-flufenicol ngokumelene namagciwane amaningi uyafana noma unamandla kunalowo we-sulfenicol, futhi amanye amagciwane amelana nama-aminool ngenxa ye-acetylation, njenge-escherichia coli ne-klebsiella pneumoniae, asengazwela ku-flufenicol.
Isetshenziselwa ikakhulukazi izifo ezibangelwa amagciwane ezingulube, inkukhu nezinhlanzi ezibangelwa amagciwane azwelayo, njengezifo zokuphefumula zezinkomo nezingulube ezibangelwa i-pasteurella hemolyticus, i-pasteurella multocida ne-actinobacillus pleuropneumoniae. I-typhoid ne-paratyphoid ebangelwa i-salmonella, ikholera yenkukhu, i-dysentery emhlophe yenkukhu, i-colibacillosis, njll; i-fish pasteurella, i-vibrio, i-staphylococcus aureus, i-hydroomonas, i-enteritis namanye amagciwane abangelwa i-fish bacterial septicemia, i-enteritis, i-erythroderma futhi maduzane.
I-Pharmacokinetics flufenicol imuncwa ngokushesha ngokuphathwa kwangaphakathi, futhi ukugxila kokwelapha kungafinyelelwa egazini ngemuva kwehora eli-1, futhi ukugcwala okukhulu kwegazi kungafinyelelwa emahoreni angama-1 kuye kwangama-3. I-bioavailability ingaphezu kwama-80%. I-Flufenicol isatshalaliswa kabanzi ezilwaneni futhi inganqamula umgoqo wegazi nobuchopho. Ikhishwa ikakhulukazi emchameni ngendlela yayo yokuqala futhi ngamanani amancane endle.
1. Ama-Macrolides nama-lincoamine anomgomo ofanayo nalo mkhiqizo, ahlanganiswe ne-bacterial ribosome 50s subunit, futhi angaveza imiphumela ephikisanayo uma ehlangene.
2. Ingase ixabanise umsebenzi wokubulala amagciwane wama-penicillin noma ama-aminoglycosides, kodwa akufakazelwanga ezilwaneni.
Ama-antibiotic e-Amidoalcohol, azwela kakhulu ku-Pasteurella hemolyticus, Pasteurella multocida kanye ne-actinobacillus pleuropneumoniae, asetshenziselwa izifo ze-Pasteurella ne-Escherichia coli.
Umjovo we-intramuscular: umthamo owodwa, isisindo somzimba esingu-1kg, 0.2ml wenkukhu, 0.15 ~ 0.2ml wezimvu nezingulube, 0.075 ~ 0.1ml wamahhashi nezinkomo. Kanye njalo emahoreni angama-48, kabili ngokulandelana. Izinhlanzi 0.005 kuya ku-0.01ml kanye ngosuku.
1. Lo mkhiqizo unomphumela othile we-immunosuppressive uma usetshenziswa ngaphezu komthamo onconyiwe.
2. Inobuthi be-fetus, futhi kufanele isetshenziswe ngokuqapha ngesikhathi sokukhulelwa kanye nemfuyo emunyisayo.
1. isikhathi sokubekela izinkukhu zokubekela asivunyelwe.
2. Izilwane ezinokuntuleka okukhulu kwamasosha omzimba noma isikhathi sokugoma kufanele zivinjelwe.
3. Izilwane ezinokwehluleka kwezinso kufanele zincishiswe ngendlela efanele noma zinwetshwe isikhathi sokuphumula sokuphatha.
