I-Pharmacodynamics enrofloxacin ingumuthi obanzi we-bactericidal wezilwane ze-fluoroquinolone. Inomphumela omuhle ku-escherichia coli, i-salmonella, i-klebsiella, i-brucella, i-pasteurella, i-actinobacillus pleuropneumoniae, i-erysipelas, i-proteus, i-serratia marcescens, i-corynebacterium pyogenes, i-portococcus septicus, i-staphylococcus aureus, i-mycoplasma, i-mycoplasma, njll. i-aeruginosa ne-streptococcus, kanye nomphumela obuthakathaka kubhaktheriya ye-anaerobic. Inomphumela osobala we-post-antibacterial kuma-bacteria azwelayo. Indlela elwa namagciwane yalo mkhiqizo ukuvimbela i-enzyme yokujikeleza kwe-bacterial dna, iphazamise ukuphindaphinda kwe-DNA yebhaktheriya, ukubhalwa kabusha nokulungisa kabusha, amabhaktheriya awakwazi ukukhula nokuzalana ngokujwayelekile futhi afe.
I-Pharmacokinetics ukumuncwa kwe-intramuscular yalo mkhiqizo kuyashesha futhi kuphelele, nge-bioavailability engu-91.9% ezingulubeni kanye nama-82% ezinkomeni zobisi. Isatshalaliswa kabanzi ezilwaneni futhi ingangena kahle ezicutshini nasemanzini omzimba, ngaphandle koketshezi lwe-cerebrospinal, ukugcwala kwezidakamizwa cishe kuzo zonke izicubu kuphezulu kunaleyo ekwi-plasma. I-metabolism yesibindi iwukukhiqiza i-ciprofloxacin ngokususa i-ethyl ye-7-piperazine ring, kulandelwa i-oxidation kanye nokubopha i-glucuronic acid. Ikhishwa ikakhulukazi yizinso (ngokukhishwa kwe-renal tubule kanye nokuhlunga kwe-glomerular), kanti i-15% kuya ku-50% ikhishwa emchameni ngendlela yayo yasekuqaleni. Ukuphila kwesigamu sokuqeda kuyahlukahluka kakhulu ezinhlotsheni ezahlukene kanye nezindlela ezahlukene zokuphatha. Ukuqedwa kwesigamu sempilo ngemuva komjovo we-intramuscular amahora angama-5.9 ezinkomeni, amahora angama-9.9 emahhashini, amahora angama-1.5 kuye kwangama-4.5 ezimvini, namahora angama-4.6 ezingulubeni.
1. Lo mkhiqizo unomphumela we-synergistic uma usetshenziswa ne-aminoglycoside noma i-broad-spectrum penicillin.
2. Ama-ion ensimbi esindayo afana ne-ca2+, mg2+, fe3+ ne-al3+ canchelate ngalo mkhiqizo futhi athinte ukumuncwa.
3. Uma ihlanganiswa ne-theophylline ne-caffeine, inganciphisa izinga lokubopha lamaprotheni e-plasma, ikhulise ngokungavamile ukugcwala kwe-theophylline ne-caffeine egazini, futhi ivele nezimpawu zobuthi be-theophylline.
4. Lo mkhiqizo unomphumela wokuvimbela ama-enzyme ezidakamizwa zesibindi, anganciphisa izinga lokusulwa kwezidakamizwa ezigaywe kakhulu esibindini futhi andise ukugcwala kwezidakamizwa egazini.
Izidakamizwa ze-antibacterial fluoroquinolone. Isetshenziselwa imfuyo kanye nezinkukhu izifo amagciwane kanye mycoplasma ukutheleleka.
Umjovo we-Intramuscular: Umthamo owodwa, 0.025ml nge-1kg isisindo somzimba wezinkomo, izimvu nezingulube; 0.025 ~ 0.05ml wezinja, amakati nonogwaja. Sebenzisa izikhathi ezi-1 kuye kwezi-2 ngosuku izinsuku ezi-2 kuye kwezi-3.
1. Ukuwohloka koqwanga ezilwaneni ezincane, okuthinta ukukhula kwamathambo futhi kubangele ukuxhwala nobuhlungu.
2. Ukusabela kwesimiso sokugaya kuhlanganisa ukuhlanza, ukulahlekelwa ukudla, isifo sohudo futhi ngokushesha.
3. Ukusabela kwesikhumba kuhlanganisa i-erythema, pruritus, urticaria kanye ne-photosensitivity.
4. Ukungezwani komzimba, i-ataxia, ukuthunjwa kubonakala ezinjeni nasemakati.
1. Inamandla okuvusa amadlingozi ohlelweni olumaphakathi, idala ukuquleka, futhi kufanele isetshenziswe ngokuqapha ezinjeni ezinesifo sokuwa.
2. Izilwane ezidla inyama nezilwane ezingasebenzi kahle kwezinso kufanele zisetshenziswe ngokuqapha, okungase kubangele umchamo ocwebile ngezikhathi ezithile.
3. Lo mkhiqizo awuwafanele amahhashi. Imijovo ye-Intramuscular i-irritants yesikhashana.
4. Lo mkhiqizo akufanele usetshenziswe ezinjeni ngaphambi kwamaviki angu-8 ubudala.
5. Izinhlobo ezimelana nezidakamizwa zalo mkhiqizo ziyanda futhi akufanele zisetshenziswe kumithamo ye-subtherapeutic isikhathi eside.
